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目的探讨单唾液酸四己糖神经节苷脂治疗新生儿窒息合并缺氧缺血性脑病(HIE)的临床疗效。方法选取2011年6月-2016年2月在陕西省汉中市人民医院新生儿科接受住院治疗的76例合并HIE的新生儿窒息患儿为研究对象,回顾性分析其临床资料。随机将患儿分为观察组(常规对症治疗+单唾液酸四己糖神经节苷脂,38例)和对照组(常规对症治疗,38例)。比较两组患儿一般资料、治疗后的临床疗效、新生儿行为神经评分法(NBNA)评分、血清糖分解烯醇酶(NSE)表达水平、S100β蛋白的表达水平、不良反应及后遗症发生情况的差异。结果观察组患儿治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿的NBNA评分、血清NSE和S100β蛋白水平比较,差异无统计学意义(P>0.05);治疗后,观察组患儿的NBNA评分明显高于对照组,血清NSE、S100β蛋白水平明显低于对照组,差异有统计学意义(P<0.05)。两组均未出现不良反应,观察组患儿的后遗症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论合并HIE的新生儿窒息患儿采用单唾液酸四己糖神经节苷脂治疗的效果显著,且安全性较高。
Objective To investigate the clinical efficacy of monosialotetrahexosyl gangliosides in the treatment of neonatal asphyxia with hypoxic-ischemic encephalopathy (HIE). Methods From June 2011 to February 2016, 76 neonates with neonatal asphyxia with HIE undergoing inpatient neonates in Hanzhong People’s Hospital of Shaanxi Province were selected as the study subjects, and their clinical data were retrospectively analyzed. The children were randomly divided into observation group (conventional symptomatic treatment + monosialotetrahexosyl ganglioside, 38 cases) and control group (conventional symptomatic treatment, 38 cases). The general data of two groups were compared, after treatment, clinical curative effect, neonatal behavioral neurological score (NBNA) score, serum level of expression of carbohydrase enolase (NSE), S100β protein expression, adverse reactions and sequelae difference. Results The total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant (P <0.05). Before treatment, there was no significant difference in NBNA score, serum NSE and S100β levels between the two groups (P> 0.05). After treatment, the NBNA score of the observation group was significantly higher than that of the control group. Serum NSE, S100β Protein levels were significantly lower than the control group, the difference was statistically significant (P <0.05). No adverse reaction was observed in both groups, and the incidence of sequelae in the observation group was significantly lower than that in the control group (P <0.05). Conclusions The treatment of neonatal asphyxia with HIE by monosialotetrahexosyl ganglioside is effective and safe.