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目的 :探讨血清基质金属蛋白酶 (MMP)在稳定型心绞痛患者中介入治疗后的表达。方法 :16例冠状动脉造影正常的患者 (对照组 )及 5 1例行冠状动脉介入治疗的稳定型心绞痛患者 (患者组 )入选 ;术后常规查肌钙蛋白I(cTnI) ,分别采取术前 ,术后第 1、第 3及第 5天的外周血 ,Elisa试剂盒测定MMP 2、MMP 9的水平。结果 :5 1例患者中共有 2 1例患者cTnI增高 ,平均 (0 .6 8± 0 .2 3) μg/L ;术前两组的MMP水平无明显差异 ;cTnI阳性者的MMP 9在术后第 1天明显高于阴性者及对照组〔(198± 5 8.5 )∶(14 4± 4 8.3)、(132± 4 6 .7) μg/L ,均 P <0 .0 5〕 ,并在术后第 3天、第 5天保持较高水平 ;MMP 2仅在术后第 1天增高 ,第 3天、第 5天恢复正常。结论 :冠状动脉介入治疗后心肌微损伤的发生率较高 ,这种心肌微损伤对患者的预后有一定的影响 ;血清MMP水平的增高 ,可能是此类患者临床预后较差的原因之一。
Objective: To investigate the expression of serum matrix metalloproteinase (MMP) in patients with stable angina pectoris after interventional therapy. Methods: Sixteen patients with normal coronary arteries (control group) and 51 patients with stable angina pectoris undergoing coronary intervention (patient group) were enrolled. Conventional cTnI levels were measured before and after surgery Peripheral blood samples were collected on the 1st, 3rd and 5th day after operation. Elisa kit was used to determine the levels of MMP 2 and MMP 9. Results: A total of 21 patients in 51 patients had higher cTnI (0.68 ± 0.23) μg / L and no significant difference in MMP levels between the two groups The first day after operation was significantly higher than that in the negative control group [(198 ± 5 8.5): (14 4 ± 4 8.3), (132 ± 46.7) μg / L, both P <0.05] On the third day after operation, the level of MMP-2 remained high on the fifth day; MMP-2 increased only on the first day after operation, and returned to normal on the third day and the fifth day. Conclusion: The incidence of myocardial micro-injury after coronary intervention is high. This micro-injury of myocardium has a certain impact on the prognosis of patients. Elevated serum MMP levels may be one of the reasons for the poor clinical prognosis of such patients.