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目的了解保定市COXA6型手足口病伴脱甲症病例的流行病学特征及相关因素,为制定防控措施提供科学依据。方法采用荧光定量RT-PCR法对2015年1月至2016年5月保定市哨点医院采集的手足口病病例咽拭子标本进行柯萨奇病毒A6型核酸检测,筛选COXA6型手足口病,并按是否伴有脱甲分为脱甲组和未脱甲组,利用检验对两组人群分布、临床特征、皮损特征及卫生行为情况进行对比分析,并利用Logistic回归分析COXA6型手足口病伴脱甲症的相关因素。结果保定市COXA6型手足口病伴脱甲症病例主要集中在5岁以内,以1~2岁患儿所占比例最高且男性多于女性。既往有皮肤过敏史(OR=5.230)、皮疹在指或趾甲周围分布(OR=10.599)和皮疹面积大于5%(OR=10.776)为COXA6型手足口病伴脱甲症病例的危险因素。结论对于既往有皮肤过敏史、皮疹在指或趾甲周围分布以及皮疹面积大于5%的COXA6型手足口病患儿要加强重视,以防其脱甲症的发生。同时在COXA6型手足口病流行期间加强的卫生防范措施,不会导致脱甲症的发生。
Objective To understand the epidemiological characteristics and related factors of COXA6 type hand-foot-and-mouth disease with dementia in Baoding city, and to provide a scientific basis for making prevention and control measures. Methods Fluorescent quantitative RT-PCR was used to detect Coxsackie virus A6-type nucleic acid in throat swabs collected from sentinel hospitals in Baoding from January 2015 to May 2016. Screening COXA6 type hand-foot-mouth disease, The patients were divided into demethylation group and non-dementia group according to whether there was dementia or not. The distribution, clinical characteristics, lesions characteristics and health behaviors of the two groups were compared and analyzed by using the test. Logistic regression analysis was used to analyze COXA6 type hand-foot-mouth disease Associated with demethylation related factors. Results Baoding COXA6 hand, foot and mouth disease with dementia cases are mainly concentrated in the 5-year-old to 1 to 2-year-old children accounted for the highest proportion and more men than women. Previously, there was a history of skin allergies (OR = 5.230). Rash was distributed around the digit or digit (OR = 10.599) and the rash area was greater than 5% (OR = 10.776) as risk factors for COXA6 HFMD with dementia. Conclusion For children with COXA6 type hand-foot-mouth disease who have a history of skin allergies, the rash is distributed around the finger or toe, and the rash area is more than 5%, care should be taken to prevent the occurrence of demethylation. At the same time strengthen the precautionary measures during the epidemic of COXA6 hand, foot and mouth disease, will not lead to the occurrence of demethylation.