噁二嗪片段常用于小分子的修饰和构象限制,同时噁二嗪也是一种理想的酰胺电子等排体.基于商品化琥珀酸脱氢酶抑制剂杀菌剂的结构框架,通过生物电子等排手段,以噁二嗪替换酰胺结构,设计并合成了24个1,2,4-噁二嗪类化合物.生物活性测试结果表明,在400 mg/L浓度下,大部分化合物对黄瓜霜霉病表现出较好的活性.此外,在600 mg/L的浓度下,这些化合物对粘虫的致死率达到100％,说明噁二嗪的结构值得作为先导继续研究,进而发现活性优异的新化合物.“,”Oxadiazine is an active fragment and usually is used for modification and conformation restriction of small mole-cules,meanwhile,it can be considered as an ideal and completely competent surrogate for the amide group.Based on the gen-eral framework of marketed succinate dehydrogenase inhibitors,twenty-four 1,2,4-oxadiazine compounds were designed and synthesized.The bioactivity test results showed that most of compounds exhibited good activities against Pseudoperonospora cubensis at 400 mg/L.In addition,the oxadiazine compounds have a 100％ mortality against armyworms at 600 mg/L,which illustrates that oxadiazine structure is worth to be a lead compound and further modification to discover novel active with prac-tical potentials.