论文部分内容阅读
目的:探讨影响宫颈癌患者新辅助化疗(NACT)敏感性的相关因素。方法:回顾分析2011年4月至2015年2月天津市中心妇产科医院收治的106例IB2~IIB期宫颈癌患者资料,行NACT 1~3个疗程,术前评价治疗效果。分析病理类型、临床分期、肿瘤直径、组织学分级、治疗前血清鳞状上皮抗原(SCC-Ag)、血红蛋白、血小板、血小板与淋巴细胞比值(PLR)与NACT敏感性的关系。结果:NACT有效率为64.15%(68/106)。NACT有效组的手术时间、术后淋巴结转移率、宫颈深间质浸润率均低于无效组(P<0.05)。单因素分析显示,治疗前肿瘤直径、SCC-Ag、PLR与宫颈癌NACT敏感性有关(P<0.05)。多因素分析显示,治疗前肿瘤直径、SCC-Ag、PLR是影响宫颈癌NACT敏感性的独立危险因素(P<0.05)。结论:治疗前肿瘤直径、SCC-Ag、PLR对宫颈癌NACT的敏感性有一定的预测价值。
Objective: To investigate the related factors affecting the sensitivity of neoadjuvant chemotherapy (NACT) in patients with cervical cancer. Methods: The data of 106 patients with stage IB2 ~ IIB cervical cancer admitted from April 2011 to February 2015 in Tianjin Obstetrics and Gynecology Hospital were analyzed retrospectively. NACT was given 1 ~ 3 courses of treatment and the therapeutic effect was evaluated preoperatively. The pathological type, clinical stage, tumor diameter, histological grade, pre-treatment serum SCC-Ag, hemoglobin, platelet, platelet to lymphocyte ratio (PLR) and NACT sensitivity were analyzed. Results: The NACT efficiency was 64.15% (68/106). The operation time, postoperative lymph node metastasis rate, cervical deep stromal infiltration rate in NACT effective group were significantly lower than those in ineffective group (P <0.05). Univariate analysis showed that tumor diameter, SCC-Ag, PLR before treatment were correlated with NACT sensitivity of cervical cancer (P <0.05). Multivariate analysis showed that tumor diameter, SCC-Ag and PLR before treatment were independent risk factors influencing NACT sensitivity of cervical cancer (P <0.05). Conclusion: The tumor diameter, SCC-Ag and PLR before treatment have certain predictive value for the sensitivity of cervical cancer NACT.