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对120例涎腺多形性腺瘤进行了临床病理分析,其中10例肿瘤和3例正常涎腺组织以KER、CEA、NSE、α_1AT、S-100和GFAP6种抗血清进行了ABC免疫组化染色观察。120例肿瘤中6例恶性(5％),3例为复发瘤恶变。根据肿瘤中主要病理成份将其分为四种亚型。腺瘤型、肌上皮型包膜多较厚而完整,浸润少,后者囊性变多。粘液型则包膜多薄弱或不完整,浸润及卫星灶多,复发和恶性瘤以此型多见。肿瘤细胞可对多种抗血清呈现不同程度和强度的阳性表达,且与正常涎腺闰管区细胞的免疫表达基本一致,说明此区可能是该肿瘤的发源地。CEA、S-100、GFAP对恶性腺瘤有较好的标记结果。
A clinicopathological analysis was performed on 120 cases of parotid pleomorphic adenomas. 10 cases of tumors and 3 cases of normal parotid glands were subjected to ABC immunohistochemical staining with KER, CEA, NSE, α_1AT, S-100 and GFAP antiserum. Observed. Of the 120 tumors, 6 were malignant (5%) and 3 were malignant of recurrent tumors. According to the main pathological components of the tumor, it is divided into four subtypes. The adenoma type and myoepithelial type envelope are mostly thick and complete with less infiltration and the latter has more cystic changes. The mucinous type has weak or incomplete capsules, infiltration and satellite foci, recurrence and malignant tumors are more common in this type. Tumor cells can express positively to various anti-sera with different degrees and intensities, and are basically consistent with the immunological expression of normal salivary fistula cells, indicating that this area may be the origin of the tumor. CEA, S-100, and GFAP have better marked results for malignant adenomas.