酪氨酸主要在肝内分解,在早产儿和肝硬化病人中,它的代谢受到抑制。肝硬化患者血清酪氨酸浓度增高被认为是引起肝性脑病的一个原因,尽管也存在相反的证据。肝硬化患者由于肝血供不足,其血浆酪氨酸廓清率降低,因而导致高酪氨酸血症。此亦可由于酪氨酸的肝内分解代谢引起。在酪氨酸的分解代谢过程中,L-酪氨酸:α-酮戊二酸盐转氨酶是首要的和起限速作用 Tyrosine is mainly degraded in the liver, and its metabolism is inhibited in preterm and cirrhotic patients. Increased serum tyrosine concentrations in patients with cirrhosis are thought to be one of the causes of hepatic encephalopathy, albeit with the opposite evidence. Patients with cirrhosis due to lack of liver blood supply, the plasma tyrosine clearance rate decreased, resulting in high tyrosinemia. This may also be due to intrahepatic catabolism of tyrosine. During tyrosine catabolism, L-tyrosine: α-ketoglutarate aminotransferase is the primary and speed-limiting effect