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目的 了解多囊卵巢综合征 (PCOS)与高胰岛素血症的关系。方法 检测记录 2 8例 PCOS患者年龄、身高、体重及体重指数 (BMI) ,放免法测定血雌 (E)、孕 (P)、雄激素 (T)、促卵泡生成素 (FSH )、促黄体生成素(L H)、泌乳素 (PRL )、游离三碘甲状腺原氨酸 (T3)、游离甲状腺素 (T4)、晨 8时及下午 4时皮质醇、空腹胰岛素及口服糖耐量试验 (OGTT)糖负荷后各时点胰岛素含量 ,用氧化酶法测定血浆葡萄糖。计算 L H/FSH比值 ,30分钟、12 0分钟、180分钟胰 /糖比 (I/G) ,胰岛素曲线下面积 (AUC)及胰岛素抵抗指数 (IRI) ,血糖水平 ,胰岛素敏感性指数 (ISI) ,胰岛β细胞功能及胰岛素抵抗指数。结果 2 8人中有 16人 (5 7.1% )同时伴有高胰岛素血症 ,其中一人有糖尿病。高胰岛素与非高胰岛素血症患者的年龄 ,身高 ,体重 ,BMI,血 E、P、T,FSH、L H、PRL、T3、T4、晨 8时及下午 4时皮质醇等无差异。但高胰岛素血症组的 L H/FSH比值为 2 .4± 1.5 ,明显高于非高胰岛素血症组 (1.2± 0 .6 ,P=0 .0 12 5 )。其空腹胰岛素 ,OGTT糖负荷后各时点胰岛素 ,30分钟、12 0分钟、180分钟 I/G,AU C及 IRI亦均高于非高胰岛素血症组。而空腹及各时点的血糖水平与非高胰岛素血症的患者无差异。此外 ,高胰岛素血症组病人的空腹胰岛素水?
Objective To investigate the relationship between polycystic ovary syndrome (PCOS) and hyperinsulinemia. Methods The age, height, weight and body mass index (BMI) of 28 PCOS patients were measured and recorded. The serum levels of E, P, T, FSH, (LH), prolactin (PRL), free triiodothyronine (T3), free thyroxine (T4), cortisol, fasting insulin and oral glucose tolerance test (OGTT) Insulin content at each time point after glucose load was measured by oxidase method. The LH / FSH ratio, 30 min, 120 min, 180 min I / G, AUC and IRI, blood glucose level, insulin sensitivity index (ISI) , Pancreatic β-cell function and insulin resistance index. Results Twenty-eight of the 16 patients (5.1 7.1%) were accompanied by hyperinsulinemia and one of them had diabetes. There was no difference in age, height, weight, BMI, blood E, P, T, FSH, LH, PRL, T3, T4, cAMP at 8:00 am and 4:00 pm in patients with hyperinsulinemia and non- hyperinsulinemia. However, the ratio of L H / FSH in hyperinsulinemia group was 2.4 ± 1.5, which was significantly higher than that in non-hyperinsulinemia group (1.2 ± 0.6, P = 0.012 5). The fasting insulin, insulin at each time point after OGTT glucose load, I / G, AU C and IRI at 30 minutes, 120 minutes and 180 minutes were also higher than those in non-hyperinsulinemia group. Fasting and blood glucose levels at each time point and non-hyperinsulinemia patients no difference. In addition, patients with hyperinsulinemia fasting insulin water?