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本文研究胰岛素对白细胞介素1(IL—1)的产生及其作用的影响.实验证实:腴岛素能促进LPS刺激的巨噬细胞IL—1的产生,并可增强胸腺细胞对Con A的反应.但用尼龙毛处理胸腺细胞除去粘附细胞后,胸腺细胞在无外源性IL—1存在时,对Con A的反应很弱.胰岛素不能增强经尼龙毛处理后的胸腺细胞对Con A的反应.加入外源性IL—1后,胰岛素可显著增强胸腺细胞对IL—1的应答,促进细胞增殖.这些结果表明。胰岛素是通过促进IL—1的产生及增强其作用来调节激活T细胞的.
In this study, we investigated the effects of insulin on the production of interleukin-1 (IL-1) and its effects in mice.It was demonstrated that 腴-insulin can promote the production of IL-1 by LPS-stimulated macrophages and enhance the effect of thymocytes on the proliferation of Con A But thymocytes reacted weakly to Con A in the absence of exogenous IL-1 after treatment of thymocytes with nylon wool to remove adherent cells.Insulin did not enhance the effect of thymus-treated thymocytes on Con A .In addition of exogenous IL-1, insulin significantly enhanced thymocyte response to IL-1 and promoted cell proliferation. Insulin regulates activated T cells by promoting IL-1 production and enhancing its effects.