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洋金花作为中药麻醉主药,其有效成分是东莨菪碱。此药为熟知的抗胆碱药,其中枢抑制作用,也与其抗胆碱作用有关(3、4)。但是,近几年来,我们也曾观察到它能拮抗儿茶酚胺的作用。由于去甲肾上腺素等为中枢化学递质,参与维持清醒状态。因此,继续进行实验,观察拟肾上腺素药物和抗肾上腺素能药物与东莨菪碱对中枢作用的相互影响,有助于探讨东莨菪碱中枢抑制作用与其抗肾上腺素能作用的关系。 方法 实验用动物为杂种家兔,雌雄不拘,体重1.7～2.2公斤。所有药物均分别从两侧侧脑室注入,容量在0.2毫升以下。观
Yang Jinhua as the main drug anesthesia, the active ingredient is scopolamine. This drug is a well-known anticholinergic and its central inhibitory effect is also related to its anticholinergic effect (3,4). However, in recent years, we have also observed that it can antagonize the effects of catecholamines. As norepinephrine and other central chemical neurotransmitters, involved in maintaining a clear state. Therefore, to continue the experiment to observe the adrenergic drugs and anti-adrenergic drugs and scopolamine on the interaction between the central role in helping to explore the scopolamine central inhibitory effect and its anti-adrenergic effects. Methods The experimental animals were hybrid rabbits, both male and female, weighing 1.7 to 2.2 kg. All drugs were injected from both sides of the lateral ventricle, the volume below 0.2 ml. View