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本病是由于胰岛的D细胞瘤GasTrinoma或D细胞增生,而产生大量的胃泌素Gastrip所引起的顽固性消化性溃疡病为特点的临床综合征。1955年首由Zollinger-Ellison二氏报告了两例。近年来随着对消化道内分泌研究及诊断技术的进展,有关本病的报导日渐增多。有人报告胰源性消化性溃疡病约占消化性溃疡病发病率的1％,大约有50％的患者死于本病的严重饼发症或多次外科手术后。本文仅通过六例病人的治疗并结合有关文献复习讨论。
The disease is a clinical syndrome characterized by intractable peptic ulcer disease caused by gastrin Gastrin in the pancreatic islets, which produces a large number of gastrin Gastrin or D cells. In 1955, two cases were reported by Zollinger-Ellison II. In recent years, with the advancement of the research on the endocrine of the digestive tract and the development of diagnostic techniques, there has been increasing reports on the disease. It has been reported that pancreatic peptic ulcer disease accounted for about 1% of the incidence of peptic ulcer disease, about 50% of patients died of severe pancake disease or multiple surgical operations after the disease. This article only discusses the treatment of six patients and review of related literature.