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目的:观察阿魏酸钠协同治疗急性脑梗死的临床疗效。方法:80例急性脑梗死患者,随机分为2组,每组各40例,两组年龄、多发和单侧脑梗塞比例、合并糖尿病、冠心病、高血压病比例等均无统计学差异(P>0.05)。对照组给予丹参注射液30ml加入生理盐水250ml中静滴,治疗组给予阿魏酸钠300mg加入生理盐水250ml中静滴,均1次/天,14天为一疗程。其间根据患者具体情况同时给予控制血压、血糖等治疗。比较观察两组治疗前后总胆固醇、甘油三酯、血液流变学指标、神经功能缺损评分等的差异。结果:治疗组和对照组患者治疗前胆固醇、甘油三酯、全血黏度、血浆黏度、神经功能缺损评分均无统计学差异(P>0.05),治疗后两组总胆固醇、甘油三酯、全血黏度、血浆黏度均有降低,神经功能缺损评分均有提高,治疗组效果明显优于对照组(P<0.01)。结论:阿魏酸钠治疗急性脑梗死的临床疗效优于丹参。
Objective: To observe the clinical efficacy of sodium ferulate in the treatment of acute cerebral infarction. Methods: Eighty patients with acute cerebral infarction were randomly divided into two groups (40 in each group). There was no significant difference in the proportions of age, multiple cerebral infarction and unilateral infarction, diabetes mellitus, coronary heart disease and hypertension among the two groups P> 0.05). The control group was given Danshen injection 30ml intravenous infusion of 250ml normal saline, the treatment group was given sodium ferulate 300mg 250ml intravenous infusion of normal saline were 1 / day, 14 days for a course of treatment. During which according to the specific circumstances of patients given at the same time control blood pressure, blood sugar and other treatment. The differences of total cholesterol, triglyceride, hemorrheological indexes and neurological deficit score before and after treatment were observed. Results: Before treatment, the treatment group and the control group had no significant difference in cholesterol, triglyceride, whole blood viscosity, plasma viscosity and neurological deficit scores (P> 0.05). After treatment, total cholesterol, triglyceride, Blood viscosity, plasma viscosity were reduced, neurological deficit scores were improved, the treatment group was significantly better than the control group (P <0.01). Conclusion: The clinical efficacy of sodium ferulate in treating acute cerebral infarction is better than that of Salvia miltiorrhiza.