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目的:观察银杏叶片对2型糖尿病患者C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)与脂联素(APN)水平的影响,探讨银杏叶片治疗2型糖尿病的可能机制。方法:将80例新诊断2型糖尿病患者随机分为治疗组和对照组2组,治疗组给予银杏叶片治疗,对照组采用罗格列嗣治疗,均治疗24周。比较2组空腹胰岛素(FINS)、空腹血糖(FBG)、胆固醇(TC)、甘油三酯(TG)、CRP、TNF-α、APN水平及胰岛素抵抗(IR)程度(用HOMA-IR表示)。结果:治疗后2组FBG、FINS、TG、TC水平均明显下降,与治疗前比较,差异有非常显著性意义(P<0.01)。2组间比较,差异无显著性意义(P>0.05)。治疗后2组CRP、TNF-α、HOMA-IR明显降低,APN明显上升,与治疗前比较,差异有非常显著性意义(P<0.01);2组间比较,差异无显著性意义(P>0.05)。结论:银杏片可以降低2型糖尿病患者CRP、TNF-α、HOMA-IR,提高2型糖尿病患者APN的水平。
Objective: To observe the effects of Ginkgo biloba leaves on the levels of C-reactive protein (CRP), tumor necrosis factor (TNF-α) and adiponectin (APN) in type 2 diabetic patients, and to explore the possible mechanism of Ginkgo biloba leaves treating type 2 diabetes. Methods: 80 patients with newly diagnosed type 2 diabetes were randomly divided into treatment group and control group 2. The treatment group was given ginkgo leaf treatment, and the control group was treated with rogegliflozin, and both were treated for 24 weeks. Two groups of fasting insulin (FINS), fasting plasma glucose (FBG), cholesterol (TC), triglyceride (TG), CRP, TNF-α, APN levels, and insulin resistance (IR) levels (represented by HOMA-IR) were compared. Results: After treatment, the levels of FBG, FINS, TG, and TC decreased significantly in the two groups, and there was a significant difference compared with that before treatment (P<0.01). There was no significant difference between the two groups (P>0.05). After treatment, CRP, TNF-α, and HOMA-IR were significantly lower in the 2 groups, and APN was significantly increased. There was a significant difference between the two groups before treatment (P<0.01). There was no significant difference between the two groups (P>0.05). 0.05). Conclusion: Ginkgo biloba can reduce CRP, TNF-α, HOMA-IR in patients with type 2 diabetes and increase the level of APN in patients with type 2 diabetes.