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采用免疫组织化学方法，研究ｒａｓ－Ｐ２１蛋白在８６例肺癌中的表达。结果表明：Ｐ２１蛋白表达总阳性率为７３．５％，其中鳞癌为７６．５％，在腺癌中表达为６４．６％，提示Ｐ２１蛋白是肺癌的一个较好的标志物。在鳞癌和腺癌之间以及肺腺癌各亚型之间，Ｐ２１蛋白的表达无明显差异（Ｐ＞０．０５），在高、中、低分化肺癌之间阳性率依次降低，但三者无显著性差异。同时Ｐ２１蛋白表达与肿瘤大小（ＰＴ）、淋巴结转移（ＰＮ）和远处转移（ＰＭ）均无关
Immunohistochemistry was used to study the expression of ras-P21 protein in 86 cases of lung cancer. The results showed that the total positive rate of P21 protein expression was 73.5%, of which squamous cell carcinoma was 76.5% and in adenocarcinoma it was 64.6%, suggesting that P21 protein is a better marker for lung cancer. There was no significant difference in the expression of P21 protein between squamous cell carcinoma and adenocarcinoma and between lung adenocarcinoma subtypes (P>0.05). The positive rate of high-, medium-, and low-differentiated lung cancers decreased in turn, but three There was no significant difference. At the same time, P21 protein expression has nothing to do with tumor size (PT), lymph node metastasis (PN) and distant metastasis (PM)