论文部分内容阅读
γδT细胞是一群异质细胞,人和小鼠不同组织部位的γδT细胞亚群表型多变、功能丰富。γδT细胞经过胸腺选择,形成IL-17+γδT细胞、IFN-γ+γδT细胞或IL-4+γδT细胞,它的分化受到很多因素的调控。γδT细胞是炎症介质IL-17的重要来源,IL-17+γδT细胞可以参与多种疾病的诱发和发展,如过敏、自身免疫性疾病,甚至恶性肿瘤。此外,它们也在宿主防御中发挥保护作用,防治传染病和诱导细胞毒性T淋巴细胞对癌症的反应。就IL-17+γδT细胞的发育、分化和调节机制以及在各种疾病中的作用进行综述。
γδT cells are a group of heterogeneous cells. The γδT cell subsets in different tissues of human and mice are phenotypically diverse and functionally rich. γδT cells undergo thymus selection and form IL-17 + γδT cells, IFN-γ + γδT cells or IL-4 + γδT cells. Its differentiation is regulated by many factors. γδT cells are an important source of inflammatory mediators IL-17. IL-17 + γδT cells can participate in the induction and development of various diseases such as allergy, autoimmune diseases and even malignant tumors. In addition, they also play a protective role in host defense, controlling infectious diseases and inducing the response of cytotoxic T lymphocytes to cancer. The development, differentiation and regulatory mechanisms of IL-17 + γδ T cells and their roles in various diseases are reviewed.