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目的:研究柠檬苦素对炎症性肠病大鼠的治疗作用。方法:Wistar大鼠40只,随机分为正常对照组、模型组、美沙拉秦组和柠檬苦素组,每组10只,其中美沙拉嗪组和柠檬苦素组分别予100 mg/kg美沙拉嗪、50 mg/kg柠檬苦素灌胃,每日1次,连续灌胃3天后,后3组予TNBS灌肠诱导建立大鼠IBD模型,造模后继续灌胃给药7天,实验终点时分析实验动物的体重、结肠长度重量比值、结肠组织病理变化。结果:与模型组比较,柠檬苦素50 mg/kg能延缓TNBS诱导的IBD模型大鼠体重下降甚至升高体重,能显著降低模型大鼠升高的结肠重量/长度比值,控制肠道炎症,限制疾病发展,减轻病理损伤。结论:柠檬苦素对TNBS诱导的IBD模型大鼠具有明显治疗作用。
Objective: To study the effect of limonin on the treatment of inflammatory bowel disease in rats. Methods: Forty Wistar rats were randomly divided into normal control group, model group, mesalazine group and limonin group, with 10 rats in each group. The rats in mesalazine group and limonin group were given 100 mg / kg Salzine and 50 mg / kg limonin were intragastrically administered once a day for 3 days. The rats in the latter three groups were given TNBS enema to induce the establishment of IBD model. At the same time, the weight of experimental animals, the length-to-weight ratio of colon and the histopathological changes of colon were analyzed. Results: Compared with the model group, limonin 50 mg / kg can delay the weight loss or even increase the body weight of rats with IBBS induced by IBS, which can significantly reduce the elevated weight / length ratio of colon in model rats, control intestinal inflammation, Limit disease development and reduce pathological damage. Conclusion: Limonin has a significant therapeutic effect on TNBS-induced IBD model rats.