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缺血性脑血管病是威胁人类健康的常见病、多发病,其主要病理基础是脑供血血管动脉粥样硬化性狭窄。胆固醇酯(CEs)在单核巨噬细胞内过度聚集形成泡沫细胞是动脉粥样硬化病变的显著特征。胆固醇酯水解酶(CEH)能够将细胞内胆固醇酯水解为游离胆固醇而排出细胞,维持细胞内脂质的稳定,抑制单核巨噬细胞的泡沫化。国外研究发现,胆固醇酯水解酶(CEH)的表达水平同动脉粥样硬化的易感性呈负相关。目前国内对CEH在AS斑块形成中的作用研究甚少,本文就近年国外对胆固醇酯水解酶在动脉粥样硬化形成中的作用研究进展作一综述。
Ischemic cerebrovascular disease is a common disease threatening human health, frequently-occurring disease, the main pathological basis of cerebral vascular vascular atherosclerotic stenosis. Cholesteryl esters (CEs) over-aggregate in monocyte-macrophages to form foam cells are notable features of atherosclerotic lesions. Cholesterol ester hydrolase (CEH) is able to hydrolyse intracellular cholesterol ester into free cholesterol to expel cells, maintain the stability of intracellular lipid and inhibit the foaming of monocyte-macrophage. Foreign studies found that the expression of cholesterol ester hydrolase (CEH) and atherosclerosis susceptibility was negatively correlated. At present, there is little research on the role of CEH in the formation of AS plaques in China. In this review, we reviewed the recent progress in the study of the role of cholesterol ester hydrolase in the development of atherosclerosis in China.