论文部分内容阅读
利用受试者工作特征（ＲＯＣ） 曲线比较１３０ 例胸腔积液患者胸水腺苷脱氨酶（ＡＤＡ） 、癌胚抗原（ＣＥＡ） 和乳酸脱氢酶（ＬＤＨ）测定值，以鉴别结核性或恶性胸水。选择错误率最小的整数界值作为诊断参考值。结果发现诊断结核性胸水ＡＤＡ 和ＣＥＡＲＯＣ曲线下面积分别为０－９３ ±０－０１ 和０－８１ ±０－０４ ，不仅都大于随机猜测面积０－５（ｚ＞２－５８ ，Ｐ＜ ０－０１） ，而且二者间的面积也有统计差异（ｚ＝ ２－７５ ， Ｐ ＜ ０－０１） ，ＬＤＨ 的ＲＯＣ 曲线下面积为０－５８ ±０－０５ ，与面积０－５ 无统计差异（ｚ＜ １－９６ ， Ｐ＞ ０－０５） ；诊断恶性胸水：ＣＥＡ和ＡＤＡＲＯＣ曲线下面积分别为０－８４ ±０－０４ 和０－９１±０－０３ ，都大于面积０－５（ｚ＞ ２－５８ ， Ｐ ＜ ０－０１） ，但二者间的面积无统计差异（ｚ＝ １－４９ ， Ｐ ＞ ０－０５） 。ＬＤＨ 的ＲＯＣ曲线下面积为０－５２ ±０－０５ ，与面积０－５ 无统计差异（ｚ＜ １－９６ ， Ｐ＞ ０－０５） 。诊断界值：ＡＤＡ鉴别结核性胸水：２０ｕ／Ｌ；ＣＥＡ鉴别恶性胸水：９－０μｇ／Ｌ。强调ＡＤＡ 增高和ＣＥＡ 降低都有助于结核性胸水的诊断，但ＡＤＡ优于ＣＥＡ；ＣＥＡ增高?
Using the receiver operating characteristic (ROC) curve to compare the values of pleural effusion adenosine deaminase (ADA), carcinoembryonic antigen (CEA) and lactate dehydrogenase (LDH) in 130 cases of pleural effusion to identify tuberculous or malignant Pleural effusion. Select the smallest integer error bound as the diagnostic reference value. The results showed that the areas under the curve of ADA and CEAROC in diagnosis of tuberculous pleural effusion were 0-93 ± 0-01 and 0-81 ± 0-04, respectively, not only greater than the random guess area 0-5 (z> 2-58, P <0- 01). There was also statistical difference between the two groups (z = 2-75, P <0-01). The area under the ROC curve of LDH was 0-58 ± 0-05, which was not statistically different from the area 0-5 z <1-96, P> 0-05). The area under the curve of CEA and ADAROC in diagnosis of malignant pleural effusion were 0-84 ± 0-04 and 0-91 ± 0-03, respectively, which were larger than the area 0-5 (z> 2-58, P <0-01), but no statistical difference between the two (z = 1-49, P> 0-05). The area under the ROC curve of LDH was 0-52 ± 0-05, with no statistical difference from 0-5 (z <1-96, P> 0-05). Diagnostic cutoffs: ADA differential tuberculous pleural effusion: 20u / L; CEA differential malignant pleural effusion: 9-0μg / L. Emphasize ADA increased and decreased CEA contribute to the diagnosis of tuberculous pleural effusion, but ADA is superior to CEA; CEA increased?