对26例慢性食管炎病人进行了双盲试验治疗,其中15例伴有基底细胞过度增生,11例伴有不典型增生。治疗组14例病人用维生素A、B_2和C治疗,对照组12例服安慰剂,疗程10个月。从治疗前后内镜和活检病理组织学变化作为疗效判断标准。无论症状、体征和组织学检查结果治疗组均较对照组有改善。但是,只有口角炎的治愈率和病理组织学改变在两组间有显著差异(P<0.05)。 Twenty-six patients with chronic esophagitis underwent double-blind treatment, of which 15 were associated with hyperplasia of basal cells and 11 were associated with dysplasia. 14 patients in the treatment group were treated with vitamin A, B 2 and C, and 12 patients in the control group were treated with placebo for 10 months. Changes in endoscopic and biopsy histopathology before and after treatment were used as criteria for evaluating efficacy. Regardless of the symptoms, signs, and histological findings, the treatment group improved compared with the control group. However, only the cure rate and histopathological changes of angular angle inflammation were significantly different between the two groups (P<0.05).