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目的了解川西地区妇女人乳头瘤病毒(Human papillomavirus,HPV)感染状况与亚型分布情况。方法采用杂交捕获2代技术(Hybri Capture 2,HC2)对2015年雅安市人民医院检查的2 000名妇女进行HPV感染和13种高危亚型、5种低危亚型检测,分析HPV感染状况和13种高危亚型、5种低危亚型分布情况。结果 2 000名妇女中,HPV阳性686例(34.30%),其中农村地区阳性率为42.48%,城市地区阳性率为26.37%(P﹤0.05);不同年龄段人群HPV阳性率差异有统计学意义(P﹤0.05),31~40岁人群HPV阳性率最高(46.15%);13个高危亚型中排前五位的分别为52型(25.95%)、58型(14.14%)、16型(10.35%)、18型(7.14%)、68型(5.25%),5个低危亚型排序分别为42型(6.12%)、11型(3.94%)、42型(2.48%)、44型(2.33%)、6型(2.33%),混合亚型12例,占1.75%。结论川西地区HPV阳性率较高,以农村地区为主,年龄以31~40岁为主,最常见的高危亚型是52型、58型、16型、18型、68型,最常见的低危亚型是42型,建议针对不同年龄群开展HPV基因亚型的常规检测。
Objective To investigate the status and subtype distribution of human papillomavirus (HPV) infection in women in western Sichuan. Methods Two hundred and thirteen high risk subtypes and five low risk subtypes were detected in 2,000 women examined by Ya’an People’s Hospital in 2015 by Hybri Capture 2 (HC2). The prevalence of HPV infection and 13 kinds of high-risk subtypes, 5 kinds of low-risk subtypes distribution. Results The HPV positive rate was 686 cases (34.30%) in 2000 women, of which the positive rate was 42.48% in rural areas and 26.37% in urban areas (P <0.05). The positive rates of HPV in different age groups were significantly different (P <0.05). The highest positive rate of HPV was found in people aged 31-40 years (46.15%). The top five of the 13 high risk subtypes were type 52 (25.95%), type 58 (14.14%), type 16 10.3%), 18 (7.14%) and 68 (5.25%) respectively. The five low risk subtypes were 42 (6.12%), 11 (3.94%), 42 (2.48% (2.33%), 6 (2.33%), mixed subtype in 12 cases, accounting for 1.75%. Conclusion The positive rate of HPV in western Sichuan is high, mainly in rural areas, with the age of 31-40 years. The most common high risk subtypes are type 52, type 58, type 16, type 18 and type 68, the most common low Type of crisis is subtype 42, it is recommended for different age groups to carry out routine testing of HPV genotypes.