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目的 :研究甲基强的松龙对Ⅳ型狼疮性肾炎 (LN)患者血浆中 1型纤溶酶原激活物抑制物 (PAI 1)的影响。方法 :应用免疫组织化学ELISA方法检测患者血浆中PAI 1含量。结果 :①LN治疗组与对照组比较 (P <0 0 1) ;②LN患者经甲基强的松龙两次冲击治疗后与治疗前分别比较 (P <0 .0 1) ;③甲基强的松龙第二次冲击治疗后 ,与对照组比较无显著性差异 (P >0 0 5 )。结论 :甲基强的松龙通过干扰纤溶酶原激活物 (PA) 纤溶酶系统 ,使LN病人血浆中PAI 1含量明显降低 ,从而发挥治疗作用。
Objective: To investigate the effect of methylprednisolone on the plasma PAI - 1 in type Ⅳ patients with lupus nephritis (LN). Methods: The content of PAI 1 in plasma was detected by immunohistochemical ELISA. Results: ①LN treatment group compared with the control group (P <0.01); ②LN patients were treated with methylprednisolone twice after treatment compared with before treatment (P <0.01); ③ strong methyl After the second shock treatment, there was no significant difference between the two groups (P> 0.05). CONCLUSION: Methylprednisolone exerts a therapeutic effect by interfering with the plasminogen activator (PA) plasmin system, resulting in a significant reduction of plasma PAI 1 levels in LN patients.