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目的:了解危重病儿血胃泌素、胰高糖素的变化及其与胃肠功能衰竭的关系。方法:应用放射免疫分析法测定了30例危重病儿及30名正常健康儿血胃泌素、胰高糖素水平并作比较。结果:①危重病儿危重期的血胃泌素、胰高糖素水平犤(1.62±0.43)ng/L,(2.3±0.5)ng/L犦均较恢复期犤(1.47±0.51)ng/L,(1.9±0.6)ng/L犦和正常组犤(1.19±0.73)ng/L,(1.9±0.4)ng/L犦明显升高(P<0.01);危重病恢复期与正常组比较无统计学差异(P>0.05);②伴胃肠功能衰竭的危重病儿血胃泌素、胰高糖素水平犤(1.67±0.51)ng/L,(2.4±0.5)ng/L犦显著高于正常组犤(1.19±0.73)ng/L,(1.9±0.4)ng/L犦(P<0.05),有胃肠功能衰竭的危重病儿血胃泌素、胰高糖素水平有高于不伴胃肠功能衰竭者犤(1.55±0.28)ng/L,(2.1±0.5)ng/L犦的趋向,但无统计学差异(P<0.05);③多器官损害组胃泌素、胰高糖素水平犤(1.66±0.47)ng/L,(2.4±0.5)ng/L犦高于单器官损害组犤(1.53±0.28)ng/L,(1.9±0.5)ng/L犦,其中胰高糖素水平增高有统计学差异(P<0.05);④病儿组及正常组胃泌素与胰高糖素水平均呈正相关(危重病组r=0.443,P<0.05,对照组r=0.832,P<0.01)。结论:危重病儿胃泌素、胰高糖素水平与病情及胃肠功能衰竭密切相关,检测血浆胃泌素、胰高糖素水平可作为反映危重病
Objective: To understand the changes of blood gastrin and glucagon in critically ill children and its relationship with gastrointestinal failure. Methods: The levels of blood gastrin and glucagon in 30 critically ill children and 30 normal healthy children were determined by radioimmunoassay and compared. Results: (1) The levels of serum gastrin and glucagon in critically ill children were significantly lower than those in recovery (1.47 ± 0.51) ng / L and (2.3 ± 0.5) ng / L, L, (1.9 ± 0.6) ng / L 犦 and normal group 犤 (1.19 ± 0.73) ng / L, (1.9 ± 0.4) ng / L 犦) were significantly higher than those in normal control group (P <0.01) (1.67 ± 0.51) ng / L and (2.4 ± 0.5) ng / L 犦, respectively. There was no significant difference between the two groups (P> 0.05). ② Serum gastrin and glucagon levels in critically ill children with gastrointestinal failure were significantly (1.19 ± 0.73) ng / L and (1.9 ± 0.4) ng / L 犦, respectively (P <0.05). Serum gastrin and glucagon levels were significantly higher in critically ill children with gastrointestinal failure (1.55 ± 0.28) ng / L and (2.1 ± 0.5) ng / L 不 in patients without gastrointestinal failure, but there was no significant difference (P <0.05). ③ The levels of gastrin, The levels of glucagon were significantly higher than those in the single organ damage group (1.36 ± 0.47 ng / L, (2.4 ± 0.5) ng / L) and (1.9 ± 0.5) ng / L 犦, (P <0.05) .④The levels of gastrin and glucagon in children and normal group were positively correlated (r = 0.443, P <0.05 in the control group, the control group r = 0.832, P <0.01). Conclusion: The levels of gastrin and glucagon in critically ill children are closely related to their illness and gastrointestinal failure. The levels of plasma gastrin and glucagon may be used as indicators of critical illness