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采用放射免疫分析和酶联免疫分析研究维甲酸对23例口腔扁平苔藓（orallichenplanus，OLP）患者IL－2、sIL－2R、TNFα水平的影响。结果发现：经维甲酸治疗后，OLP患者的血清IL－2、sIL－2R、TNFα水平显著下降（P＜0.01），临床显效率69．6％（16／23），有效率26.1％（6／23）。提示维甲酸可以抑制OLP患者过强的T细胞增殖反应，减轻细胞因子对口腔粘膜的损害。
The effects of retinoic acid on the levels of IL-2, sIL-2R and TNFα in 23 patients with oral lichen planus (OLP) were studied by radioimmunoassay and enzyme-linked immunosorbent assay. The results showed that the levels of IL-2, sIL-2R and TNFα in OLP patients decreased significantly (P <0.01), and the clinical effective rate was 69.6% (16/23), the effective rate was 26.1% (6 /twenty three). Tip Retinoic acid can inhibit OLP patients with excessive T cell proliferation response, reduce cytokine damage to the oral mucosa.