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用ＳＰＡ—ＣｏＡ检测血清中伤寒杆菌抗原并与细菌培养和肥达氏试验对１０７例病人标本同时检测，ＳＰＡ—ＣｏＡ的敏感度、约登指数等效益指标及检测阳性率均优于两法，对７８例１周内发病的早期患者标本测定，ＳＰＡ—ＣｏＡ捡出阳性率显著高于细菌培养和肥达氏反应，阳性检出最早在病后４天。提示：ＳＰＡ—ＣｏＡ用于伤寒病早期诊断敏感度高、特异度好、方法简便、快速经济。
SPA-CoA was used to detect Salmonella typhi antigen, and bacterial culture and Widal’s test were performed on 107 patients simultaneously. The sensitivity and the Youden index of SPA-CoA were higher than those of two methods, The positive rate of SPA-CoA was significantly higher than that of bacterial culture and Widal’s reaction in 78 patients with early onset of disease in 1 week. The positive detection was the earliest 4 days after the illness. Tip: SPA-CoA for the early diagnosis of typhoid fever, high sensitivity, specificity, method is simple, fast and economical.