用成年Wistar大鼠脑内注射胶原酶法制作脑出血模型 ,观察中药醒脑健神胶囊、清开灵注射液和中风脑得平冲剂对脑出血大鼠脑内皮细胞的因子Ⅷ相关蛋白(vWF)及胶质细胞内的胶质纤维酸性蛋白 (GFAP)的影响。结果给药组与对照组比较vWF阳性新生血管增多 ,GFAP阳性细胞胞体明显增大 ,纤维显著增粗。提示 3种方药皆可激活内皮细胞和胶质细胞 ,促进坏死组织吸收、血管增生和脑组织修复 An intracerebral hemorrhage model was established by intracerebral injection of collagenase from adult Wistar rats to observe the factor VIII-related protein (vWF) of brain endothelial cells in rats with intracerebral hemorrhage by taking Xingnaojianshen Capsule, Qingkailing Injection and Zhongfeng Naodeping Granules. ) and the effect of glial fibrillary acidic protein (GFAP) in glial cells. Results Compared with the control group, vWF-positive neovascularization was increased in the administration group and the GFAP positive cell body was significantly increased, and the fiber was significantly thickened. It is suggested that all three prescriptions can activate endothelial cells and glial cells to promote the absorption of necrotic tissue, vascular proliferation and brain tissue repair.