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目的 :探讨干扰素 (IFN)联合顺铂 (DDP)加 5-氟脲嘧啶 ( 5 FU)腹腔化疗治疗卵巢癌合并腹水的临床疗效。方法 :将 36例卵巢癌合并腹水患者随机分为两组 ,先将腹水尽量放尽。PF组 :腹腔灌注DDP 80mg +5 FU 10 0 0mg +生理盐水 150 0ml ,合并IFN组在PF组基础上加用α 2b IFN 60 0万IU ,两组均每周用药 1次 ,共 3次。治疗 3个疗程后 7～ 14d评定疗效 ,并对两组腹腔化疗后行手术治疗的标本进行病理形态观察。结果 :合并IFN组腹水消退率为 70 % ,肿瘤消退率为 30 % ,均高于PF组 ,差异均有显著性 (分别为P =0 .0 4 2 ;P =0 .0 2 0 ) ;镜检其癌细胞Ⅲ +Ⅳ级反应率明显高于PF组 (P =0 .0 2 8)。结论 :IFN联合PF腹腔化疗治疗卵巢癌合并腹水安全有效 ,值得推广
Objective: To investigate the clinical efficacy of interferon (IFN) combined with cisplatin (DDP) plus 5-fluorouracil (5 FU) intraperitoneal chemotherapy in the treatment of ovarian cancer with ascites. Methods: 36 cases of ovarian cancer with ascites were randomly divided into two groups, ascites as much as possible. PF group: intraperitoneal perfusion of DDP 80mg +5 FU10 0mg + saline 150ml, combined with IFN group on the basis of the PF group with α 2b IFN 60 million IU, two groups were administered once a week for 3 times. After 3 courses of treatment, the curative effect was evaluated from 7 to 14 days, and the pathological changes of the two groups were observed after surgical treatment. Results: The ascites regression rate was 70% and the tumor regression rate was 30% in the combined IFN group, which were significantly higher than those in the PF group (P = .042 and P = .020, respectively). Microscopic examination of the cancer cells Ⅲ + Ⅳ grade response rate was significantly higher than the PF group (P = 0.028). Conclusion: IFN plus PF intraperitoneal chemotherapy is safe and effective in the treatment of ovarian cancer with ascites, which is worthy of promotion