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目的探讨肝源性糖尿病的临床特点和治疗方法。方法回顾性分析38例肝源性糖尿病患者的临床资料。结果 7例患者经护肝及控制饮食,2周内血糖正常,肝功能明显好转,4周后血糖及肝功能均正常。26例患者经护肝及胰岛素治疗4周后血糖及肝功能均恢复正常。4例患者经多次调整胰岛素剂量,血糖始终未恢复正常。1例患者治疗无效死亡。结论肝源性糖尿病患者以中老年男性为主,糖尿病的临床表现多不典型,肝功能反复异常,经积极治疗多数患者的肝病与糖尿病的病情均能得到有效控制。血糖的变化与慢性肝病的变化有关,肝源性糖尿病的治疗应该肝病与糖尿病的治疗二者兼顾。
Objective To investigate the clinical features and treatment of liver-derived diabetes. Methods The clinical data of 38 patients with liver-derived diabetes were retrospectively analyzed. Results Seven patients were protected by the liver and controlled diet. The blood glucose was normal within 2 weeks and the liver function improved obviously. After 4 weeks, the blood glucose and liver function were normal. Twenty-six patients returned to normal after 4 weeks of treatment with hepatoprotective and insulin therapy. Four patients after repeated adjustment of insulin dose, blood glucose has not returned to normal. One patient died of ineffective treatment. Conclusions Hepatogenic diabetes is mainly characterized by middle-aged and elderly men. The clinical manifestations of diabetes are atypical and the liver function is abnormal repeatedly. The majority of patients with active liver disease and liver disease can be effectively controlled. Changes in blood glucose and changes in chronic liver disease, liver-derived diabetes treatment should be both liver disease and diabetes treatment.