论文部分内容阅读
蛋白酶的一种有兴趣的潜在用途,就是对一些药物包括抗生素的增效作用。 1963年Seneca及Peer首次报道,26例病人在口服四环素250毫克之前2小时,给以40毫克糜蛋白酶的肠衣片剂。2小时后血中四环素浓度平均增加55％,4小时后增加29％。另一组4个病人两药同时服用,2小时后竟增加233％,4小时后增加115％。作者认为,血浓度的增加是由于肠道内吸收的增加。一年后他们又发表以糜蛋白酶与四环素在24小时内同时给药的报道。所有病例的四环素血浓度均有明显增加。还测定了尿中四环素含量,给药2小时后的浓度增加244％,
An interesting potential use of proteases is the synergistic effect of some drugs, including antibiotics. Seneca and Peer first reported in 1963 that 26 patients were given enteric-coated tablets with 40 mg of chymotrypsin 2 hours prior to 250 mg of oral tetracycline. After 2 hours, the concentration of tetracycline in blood increased by 55% on average and 29% after 4 hours. Another group of 4 patients taking both drugs at the same time, actually increased 233% after 2 hours, an increase of 115% after 4 hours. The author believes that the increase in blood concentration is due to increased intestinal absorption. A year later they also reported the simultaneous administration of chymotrypsin and tetracycline within 24 hours. All cases of tetracycline blood concentrations were significantly increased. Tetracycline levels in urine were also measured, with a 244% increase in concentration after 2 hours of administration,