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美国贝塞斯达消息:治疗小细胞肺癌的新概念是根据恶性肿瘤经常产生“自身分泌”因子(autocrinefactor)的证据而提出的,将很快在人体进行试验。自70年代末以来,据研究人员推测,至少某些恶性肿瘤是由刺激生长的多肽类所引起。多肽类是上述因子作用的同一肿瘤细胞所释出。目前这种肿瘤自身分泌因子的直接证据已在小细胞肺癌研究中发现。国立癌症研究所(NCI)附属海军肿瘤学分所的James L Mulshine称,与蛙皮素有关的一种两栖动物神经肽类的高浓度物质,已在大约80％的小细胞肺癌中检出。有人认为,此物质大概是胃泌素-释放肽(GRP)。在小
Bethesda, United States: The new concept for the treatment of small cell lung cancer is based on evidence that malignant tumors often produce “autocrine factors” and will soon be tested in humans. Since the late 1970s, researchers have speculated that at least some malignancies are caused by growth-promoting peptides. Polypeptides are released by the same tumor cells that act on the above factors. Current direct evidence of this tumor’s own secreted factor has been found in the study of small cell lung cancer. James L. Mulshine of the Naval Cancer Unit of the National Cancer Institute (NCI) said that a high concentration of neuropeptides related to bombesin in amphibians has been detected in approximately 80% of small cell lung cancers. Some people think that this substance is probably gastrin-releasing peptide (GRP). In small