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例1.女62岁。为治疗甲真菌病,服伊康唑100mg,每日2次。5周后诉不适、恶心、右胁痛,大便呈灰白色、尿色深,停用伊康唑。无酗酒、手术或输血史,亦未用过其他药物。实验室检查碱性磷酸酶593U/L(正常40～120U/L),天冬氨酸氨基转移酶124U/L(正常<25U/L)。丙氨酸氨基转移酶227U/L(正常<25U/L)。超声检查发现肝脏轻度增大。2周后出现瘙痒,体重减轻和黄疸。总胆红素和结合胆红素分别增至97μmol/L 和80μmol/L,2个月以后各实验室指标均正常。
Example 1. Female 62 years old. For the treatment of onychomycosis, serving Iaconazole 100mg, 2 times a day. 5 weeks after the complaint discomfort, nausea, right hypochondriacal, stool was gray, dark urine, disable the use of Iaconazole. No alcoholism, surgery or blood transfusion history, nor any other drugs. Laboratory tests alkaline phosphatase 593U / L (normal 40 ~ 120U / L), aspartate aminotransferase 124U / L (normal <25U / L). Alanine aminotransferase 227U / L (normal <25U / L). Ultrasound examination revealed a slight increase in the liver. Pruritus, weight loss and jaundice occurred after 2 weeks. Total bilirubin and conjugated bilirubin were increased to 97μmol / L and 80μmol / L, two months after the laboratory indicators were normal.