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目的探讨组织多肽特异性抗原(TPS)检测在非小细胞肺癌中的临床意义。方法选取本院自2012年1月~2013年1月收治的40例非小细胞肺癌患者作为观察组,同时选取40例同期住院治疗的良性肿瘤患者为常规组,并以40例健康体检人员作为对照组,对两组患者血清中的组织多肽特异性抗原含量及组织多肽特异性抗原阳性率进行对比。结果观察组患者的TPS含量及阳性率均明显高于常规组及对照组(P<0.05),观察组患者中临床Ⅲ-Ⅳ期患者的TPS浓度及TPS阳性率均明显高于临床Ⅰ~Ⅱ期患者(P<0.05);治疗后患者的TPS浓度及TPS阳性率均明显低于治疗前(P<0.05)。结论非小细胞肺癌患者的组织多肽特异性抗原的含量较高,且具有较高的阳性检出率,其在非小细胞肺癌患者的临床诊断中有着非常重要的意义。
Objective To investigate the clinical significance of tissue polypeptide-specific antigen (TPS) detection in non-small cell lung cancer. Methods Forty patients with non-small cell lung cancer who were treated in our hospital from January 2012 to January 2013 were selected as the observation group. Forty patients with benign tumors undergoing hospitalization in the same period were selected as the routine group and 40 healthy people as the control group The control group, the two groups of patients with serum tissue polypeptide-specific antigen content and tissue peptide-specific antigen-positive rate were compared. Results The TPS content and the positive rate in the observation group were significantly higher than those in the conventional group and the control group (P <0.05). The TPS concentration and the positive rate of TPS in the patients in the observation group were significantly higher than those in the clinical Ⅰ ~ Ⅱ (P <0.05). After treatment, the TPS concentration and TPS positive rate were significantly lower than those before treatment (P <0.05). Conclusion The content of tissue polypeptide-specific antigen in patients with non-small cell lung cancer is high and has a high positive detection rate. It is of great significance in the clinical diagnosis of patients with non-small cell lung cancer.