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目的探讨survivin、VEGF及Ki67在宫颈鳞癌中的表达及相关性。方法采用免疫组化SP法检测46例宫颈鳞癌,17例子宫颈上皮内瘤样变和21例慢性子宫颈炎组织中survivin,VEGF及Ki67抗原的表达水平。结果从慢性子宫颈炎到宫颈鳞癌,survivin表达阳性率呈逐渐升高趋势。survivin表达与宫颈鳞癌临床分期及肿瘤分级密切相关。survivin表达与宫颈鳞癌增殖活性密切相关,survivin阳性肿瘤平均KI(43.1±6.4)%明显高于survivin表达阴性肿瘤(22.3±7.5)%(P<0.05);宫颈鳞癌组织中survivin表达与VEGF表达呈正相关(r=0.358,P<0.05)。结论 survivin在宫颈鳞癌中的表达明显高于慢性子宫颈炎组织和CIN组织,survivin阳性表达与宫颈鳞癌的临床分期、分化及增殖有关,是评估预后的有效参考指标。survivin与VEGF在宫颈鳞癌中表达呈正相关,在宫颈鳞癌的发生发展中可能存在协同作用。
Objective To investigate the expression and correlation of survivin, VEGF and Ki67 in cervical squamous cell carcinoma. Methods Immunohistochemical SP method was used to detect the expression of survivin, VEGF and Ki67 in 46 cases of cervical squamous cell carcinoma, 17 cases of cervical intraepithelial neoplasia and 21 cases of chronic cervicitis. Results From chronic cervicitis to cervical squamous cell carcinoma, the positive rate of survivin expression gradually increased. The expression of survivin is closely related to the clinical stage and tumor grade of cervical squamous cell carcinoma. The expression of survivin was closely related to the proliferation of cervical squamous cell carcinoma. The average KI of survivin-positive tumors was significantly higher than that of survivin-positive tumors (43.3 ± 6.4% vs 22.3 ± 7.5%, P <0.05) The expression was positively correlated (r = 0.358, P <0.05). Conclusion The expression of survivin in cervical squamous cell carcinoma is significantly higher than that in chronic cervicitis and CIN. The positive expression of survivin is correlated with the clinical stage, differentiation and proliferation of cervical squamous cell carcinoma, which is a valid reference index for prognosis. The expression of survivin and VEGF in cervical squamous cell carcinoma is positively correlated, and there may be synergistic effect in the occurrence and development of cervical squamous cell carcinoma.