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目的：观察人参二醇组皂甙对心肌缺血再灌注损伤犬心功能的保护作用。方法：１２只杂种犬随机分为人参二醇组皂甙治疗组（ＰＤＳ）和生理盐水对照组（ＮＳ）。结扎冠状动脉左前降支使心肌缺血，９０ｍｉｎ后恢复血流，复制缺血再灌注损伤模型。分别于缺血即刻静脉滴注ＰＤＳ（２５ｍｇ／ｋｇ）和１００ｍｌ生理盐水。结果：ＰＤＳ组缺血再灌注后ＬＶＳＰ、±ｄｐ／ｄｔｍａｘ、ＣＯ、ＣＩ、ＳＩ均显著高于ＮＳ组，而ＬＶＳＰ和ＴＰＶＲ则明显低于ＮＳ组。结论：提示ＰＤＳ具有保护缺血再灌注损伤心肌心功能的作用。
Objective: To observe the protective effect of Panaxadiol saponin on heart function of myocardial ischemia-reperfusion injury in dogs. Methods: Twelve dogs were randomly divided into two groups: PDS group and NS group. Ligation of the left anterior descending coronary artery to myocardial ischemia, 90min after the restoration of blood flow, replication-ischemia-reperfusion injury model. Immediate intravenous infusion of PDS (25 mg / kg) and 100 ml of saline, respectively, were performed on ischemia. Results: LVSP, ± dp / dtmax, CO, CI and SI in PDS group were significantly higher than those in NS group, while LVSP and TPVR were significantly lower than those in NS group. Conclusion: It suggests that PDS can protect the cardiac function of myocardial ischemia-reperfusion injury.