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目的:观察人参二醇组皂甙对心肌缺血再灌注损伤犬心功能的保护作用。方法:12只杂种犬随机分为人参二醇组皂甙治疗组(PDS)和生理盐水对照组(NS)。结扎冠状动脉左前降支使心肌缺血,90min后恢复血流,复制缺血再灌注损伤模型。分别于缺血即刻静脉滴注PDS(25mg/kg)和100ml生理盐水。结果:PDS组缺血再灌注后LVSP、±dp/dtmax、CO、CI、SI均显著高于NS组,而LVSP和TPVR则明显低于NS组。结论:提示PDS具有保护缺血再灌注损伤心肌心功能的作用。
Objective: To observe the protective effect of Panaxadiol saponin on heart function of myocardial ischemia-reperfusion injury in dogs. Methods: Twelve dogs were randomly divided into two groups: PDS group and NS group. Ligation of the left anterior descending coronary artery to myocardial ischemia, 90min after the restoration of blood flow, replication-ischemia-reperfusion injury model. Immediate intravenous infusion of PDS (25 mg / kg) and 100 ml of saline, respectively, were performed on ischemia. Results: LVSP, ± dp / dtmax, CO, CI and SI in PDS group were significantly higher than those in NS group, while LVSP and TPVR were significantly lower than those in NS group. Conclusion: It suggests that PDS can protect the cardiac function of myocardial ischemia-reperfusion injury.