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对４６例全面性强直－阵挛发作病人进行血中三碘甲状腺原氨酸（Ｔ３）、甲状腺素（Ｔ４）、甲状腺刺激激素（ＴＳＨ）检测，结果发现血中Ｔ３、Ｔ４、ＴＳＨ水平与健康对照组相比无统计学差异（Ｐ＜０．０５），提示对垂体－甲状腺轴的功能没有影响；３０例病人经苯妥英钠、卡马西平、丙戊酸钠治疗后，Ｔ３、ＴＳＨ水平无变化（Ｐ＞０．０５），而Ｔ４水平明显下降，治疗时间越长，下降越明显（Ｐ＜０．０１），提示抗癫痫药物影响垂体－甲状腺轴的功能，使激素的分泌发生紊乱，随治疗时间的延长，药物对激素分泌的影响就越大。
The blood levels of T3, T4 and TSH in 46 patients with tonic-clonic seizures were measured. The levels of T3, T4 and TSH in blood and the levels of thyroid stimulating hormone There was no significant difference between the two groups (P <0.05), suggesting no effect on the function of pituitary-thyroid axis. After treatment with phenytoin sodium, carbamazepine and valproate, the levels of T3 and TSH (P> 0.05), while the level of T4 decreased significantly. The longer the treatment time was, the more obvious the decline was (P <0.01), suggesting that antiepileptic drugs affect the function of pituitary-thyroid axis, With the extension of treatment time, the greater the impact of drugs on hormone secretion.