进入本世纪以来,无机药物及相关基础研究获得巨大的发展,同时也面临着巨大的困难。本文综述了两类金属药物——抗癌金属药物和抗糖尿病钒化合物的研究进展和目前存在的严重瓶颈问题,并提出未来发展应重视下列方面:(1)发现新的金属药物分子机制,在此基础上实现理性药物设计;(2)基于分子机理实现对金属药物毒性的控制;(3)理性设计和建立基于纳米、分子复合物和药物分子转运体的新的金属药物转运体系;(4)发展金属配合物的合成生物学。 Since entering this century, great progress has been made in the research of inorganic drugs and related basic research, meanwhile, it is also facing great difficulties. This article reviews the progress of the two types of metal drugs - anticancer metal drugs and anti-diabetic vanadium compounds and the current serious bottlenecks, and points out the following aspects should be emphasized in the future development: (1) to discover new molecular mechanisms of metal drugs, (2) to control the toxicity of metal drugs based on molecular mechanism; (3) to rationally design and establish a new metal drug delivery system based on nanometer, molecular complex and drug molecule transporter; (4) Development of synthetic biology of metal complexes.