三氧化二砷 (As2 O3 )治疗急性早幼粒细胞白血病及实体肿瘤的主要作用机制为诱导细胞凋亡。活性氧(ROS)被认为是细胞凋亡的信号传导分子之一。细胞内氧化还原调节可决定细胞的生存状态。肿瘤细胞对As2 O3的敏感性与其自身的ROS和谷胱甘肽水平相关。小剂量维生素C亦具有促氧化作用 ,可增加体内ROS水平 ,提高肿瘤细胞对As2 O3 的敏感性 Arsenic trioxide (As2 O3) treatment of acute promyelocytic leukemia and solid tumors the main mechanism of action for the induction of apoptosis. Reactive oxygen species (ROS) is considered as one of the signal transduction molecules of apoptosis. Intracellular redox regulation can determine the state of survival of cells. The sensitivity of tumor cells to As2 O3 correlates with its own ROS and glutathione levels. Small doses of vitamin C also have the role of pro-oxidant, can increase the level of ROS in vivo and improve the sensitivity of tumor cells to As2O3