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采用一次性被动回避条件反应—跳台法及避暗法的行为实验和5种化学药物所致记忆障碍的模型,观察了葫芦科植物绞股蓝的3种提取剂及单体Rb_1对小鼠学习记忆的影响。结果表明绞股蓝3种提取剂均可改善樟柳碱引起的记忆获得障碍;Rb_1可对抗30％乙醇和戊巴比妥钠所致记忆获得障碍;绞股蓝20％醇提剂对蛋白合成抑制剂(环已酰亚胺、氯霉素)造成的记忆巩固不良以及20％乙醇引起的记忆再现障碍均有拮抗作用。
A one-time passive avoidance response-jump-table method and avoidance behavior test and five kinds of chemical-induced memory disorders model were observed gourd plant Gynostemma pentaphylla 3 extractant and monomer Rb_1 on mice learning and memory influences. The results showed that Gynostemma pentaphyllum 3 extractants could improve anisodine-induced memory impairment; Rb 1 could resist the memory impairment caused by 30% ethanol and pentobarbital sodium; Gynostemma pentaphyllum 20% Has imide, chloramphenicol) caused by poor memory consolidation and 20% ethanol-induced memory impairment disorders have antagonistic effect.