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应用放射免疫分析法（ＲＩＡ）动态观察３０例脑梗塞患者血浆内皮素－１（ＥＴ－１）、Ｐ物质（ＳＰ）含量，其结果表明：（１）急性期血浆ＥＴ－１、ＳＰ含量显著高于对照组。（２）急性期血浆ＥＴ－１含量显著高于恢复期，ＳＰ含量显著低于恢复期。（３）急性期血浆ＥＴ－１含量与ＳＰ含量呈正相关。结果提示ＥＴ－１、ＳＰ共同参与和影响脑梗塞的病理生理过程，血浆ＥＴ－１、ＳＰ含量的增高在一定程度上反映了脑梗塞的严重程度。
The levels of endothelin-1 (ET-1) and substance P in 30 patients with cerebral infarction were dynamically observed by radioimmunoassay (RIA). The results showed that: (1) Higher than the control group. (2) The content of plasma ET-1 in acute phase was significantly higher than that in recovery phase, and the content of SP was significantly lower than that in recovery phase. (3) Acute phase of plasma ET-1 content and SP content was positively correlated. The results suggest that ET-1 and SP participate in and affect the pathophysiological process of cerebral infarction. The increase of ET-1 and SP in plasma reflects the severity of cerebral infarction to a certain extent.