肝纤维化不但破坏肝脏结构,还能损害肝脏功能,和许多慢性肝疾病密切相关。肝细胞是维持肝内代谢平衡的关键,但是肝细胞在肝纤维化过程中的作用一直不甚清楚。在肝细胞行使功能的过程中,肝脏内广泛存在的转录因子HNF1α起着至关重要的作用。以往研究表明HNF1α对肝癌有显著的抑制作用,近期Cell Research发表的第二军医大学谢渭芬实验室的研究成果显示,HNF1α的表达能够显著抑制人和 Liver fibrosis not only damages the liver but also damages liver function, which is closely related to many chronic liver diseases. Hepatocytes are the key to maintaining a balanced intrahepatic metabolism, but the role of hepatocytes in liver fibrosis has been unclear. HNF1α, a transcription factor widely present in the liver, plays a crucial role in the function of liver cells. Previous studies have shown that HNF1α significantly inhibited liver cancer, the recent Cell Research published Xie Weifen Second Military Medical University research shows that the expression of HNF1α can significantly inhibit human and