作者在进行癌光啉(代号PsD-007)临床前毒性实验中发现,狗静脉注射(ⅳ)癌光啉15mg/kg可引起呕吐。据报道,临床应用血卟啉类光敏剂亦有少数患者产生恶心、呕吐。为此,作者对癌光啉的呕吐反应及其药物拮抗进行了实验研究,并探讨了呕吐反应的可能机理。 实验表明:狗ⅳ癌光啉5mg/kg可引起呕吐,剂量增加,呕吐反应加重,2.5mg In the preclinical toxicity experiment of cancer photorin (PsD-007), the authors found that intravenous injection of (iv) carboline 15mg/kg can cause vomiting. According to reports, there are also a small number of patients with clinical use of hematinoid photosensitizer nausea and vomiting. To this end, the authors conducted an experimental study of the vomiting response and the drug antagonism of carboline, and discussed the possible mechanism of vomiting reaction. Experiments showed that dog iv carboline 5mg/kg can cause vomiting, increased dose, increased vomiting reaction, 2.5mg