论文部分内容阅读
028 请提供口服维甲酸类衍生物治疗银屑病及扁平苔癣的资料 维甲酸的局部应用已推广为一种治疗手段,虽然其作用机制未明,该药的刺激作用使其临床效果受到一定限制,口服维甲酸类药物治疗各种不同的皮肤病正在研究中。RO_(10-9359)是一个正在研究中的衍生物,在动物实验中发现本品比其他维甲酸类药有更好的治疗作用。 Frederiksson和Pettersson在严重性、慢性、全身性的银屑病患者中,用口服RO_(10-9359)进行了研究。他们发现每日剂量在75-100mg时,证明该药是一个强有力的抗银屑病药物。在接受此药的20例中有10例皮损减少90％以上。
028 Oral Retinoic Acid Derivatives for the Treatment of Psoriasis and Lichen Planus Topical use of retinoic acid has been promoted as a treatment and although its mechanism of action is unknown, the drug’s stimulatory effect limits its clinical effectiveness Oral retinoids are currently being studied in the treatment of various skin disorders. RO_ (10-9359) is a derivative under study. It has been found in animal experiments that it has a better therapeutic effect than other retinoids. Frederiksson and Pettersson studied oral, RO_ (10-9359) in patients with severe, chronic, and systemic psoriasis. They found that the drug was a potent anti-psoriasis drug when it was administered at 75-100 mg daily. Ten of the 20 patients who received the drug had a 90% reduction in their lesions.