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建立一种双抗夹心酶免法测定46例糖尿病患者血清Ⅳ型胶原（cⅣ）含量。结果表明，糖尿病患者血清cⅣ含量显著高于正常对照组（P＜0．01），且随病程加长cⅣ水平逐渐升高。尿蛋白阳性的糖尿病患者血清cⅣ含量显著高于尿蛋白阴性组。研究提示血清cⅣ可作为监测糖尿病并发症指标。
To establish a double-antibody sandwich enzyme immunoassay to determine the serum level of type Ⅳ collagen (cⅣ) in 46 patients with diabetes mellitus. The results showed that the level of serum cⅣin diabetic patients was significantly higher than that of the normal control group (P <0.01), and the level of cⅣincreased gradually with the prolonged course of diabetes. Urinary protein positive diabetic patients serum cⅣ content was significantly higher than the urine protein negative group. Research suggests that serum c Ⅳ can be used as an indicator of diabetic complications.