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探讨自制的磁性平阳霉素微球（MPMS）治疗海绵状血管瘤的可行性及机理。方法：制备磁性平阳霉素微球并检测其特性。在外加磁场（025T）下，将MPMS、空白磁球、平阳霉素、生理盐水分别注入兔耳静脉，28天后取材，光镜及电镜下观察兔耳静脉系统的组织学变化。结果：磁球是圆球状，粒径为4.74～66．33μm，分散性能好；MPMS中各成份含量为：Fe_3O_411．7％，PYM3．8％，明胶84．5％；3h内MPMS释放PYM占其总量的63．1％。MPMS、空白磁球、平阳霉素对血管壁均具有一定损伤作用，其中以MPMS组最为显著。结论：MPMS各组份合理，具有较好的缓释性能，可能是海绵状血管瘤硬化治疗的一种较为理想的药物剂型。
To investigate the feasibility and mechanism of home-made magnetic pingyangmycin microspheres (MPMS) in the treatment of cavernous hemangiomas. Methods: Magnetic pingyangmycin microspheres were prepared and their characteristics were tested. Under the applied magnetic field (025T), MPMS, blank magnetic ball, pingyangmycin and normal saline were injected into the rabbit’s ear veins respectively. After 28 days, the morphological changes of the rabbit’s ear veins were observed under light microscope and electron microscope. Results: The magnetic spheres were spherical and the particle size was 4.74 ~ 66.33μm with good dispersibility. The content of each component in MPMS was Fe_3O_411.7%, PYM3.8% and gelatin 84.5% The total amount of 63.1%. MPMS, blank magnetic ball, pingyangmycin have certain damage on the vessel wall, which was the most significant MPMS group. Conclusion: The components of MPMS are reasonable and have good sustained-release properties and may be an ideal drug dosage form for the treatment of cavernous hemangioma sclerosis.