论文部分内容阅读
作者扼要地回顾了前人对抗性机理的研究与假说,特别重视硷性抗疟药的抗性产生与细胞内、外pH之间的关系。Rollo(1968)曾推测感染原虫的红细胞内液体部分的pH较细胞外液的pH为低,于是象氯喹一类硷性药物就弥散到较酸性的区域,并与细胞基质相结合而发挥作用。红细胞与疟原虫都要进行糖酵解,最终的代谢产物为乳酸。乳酸的电离常数为3.02时,就阻碍了药物从细胞内向外弥散,由此可证明细胞内的pH较低。如果疟原虫抗性株已能使乳酸盐便于弥散,
The author briefly reviews the previous studies on the mechanism of confrontation and hypothesis, with particular emphasis on the relationship between the production of alkaline antimalarial drug resistance and intracellular and extracellular pH. Rollo (1968) speculated that the pH of the liquid part of the erythrocytes infected with the protozoa was lower than the pH of the extracellular fluid so that a class of basic drugs like chloroquine diffused into the more acidic areas and interacted with the cell matrix. Erythrocytes and Plasmodium are subject to glycolysis, the final metabolite of lactic acid. When the ionization constant of lactic acid is 3.02, the drug is prevented from being diffused from the inside of the cells, which proves that the intracellular pH is low. If the Plasmodium resistant strain has been able to facilitate the dispersion of lactate,