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血道高转移瘤株FC、淋巴合并血道高转移瘤株U14、淋巴道高转移瘤株H22、非转移瘤株P615分别接种于336只纯系近交615小鼠.不同时间取血并处死动物,进行组织学及血液流变学检查.将转移瘤发展过程分为潜伏期、侵袭期、转移早、中、晚期,非转移瘤发展过程分为潜优期、增殖期、囊腔形成期及中心坏死期.本实验结果显示,不同转移能力及途径肿瘤发展的不同时期血液流变学变化规律不同,因而表明肿瘤侵袭、转移与血液流变学变化之间存在互为因果的紧密关系.其临床诊断及治疗意义被讨论.
Hematogenous metastatic tumor strain FC, lymphatic associated with hematogenous metastatic tumor line U14, lymphatic metastatic tumor line H22, and non-metastatic tumor line P615 were inoculated into 615 purebred inbred 615 mice respectively.All the animals were sacrificed at different times, Histological and hemorheological examination.The development of metastatic tumor was divided into latent period, invasive period, early metastasis, middle and late stage, and the development of non-metastatic tumor was divided into latent period, proliferative period, cyst formation and central necrosis The experimental results show that different metastatic capacity and pathways of different stages of tumor development of different changes in hemorheology, indicating that there is a causal relationship between tumor invasion, metastasis and hemorheology changes in the clinical diagnosis And the therapeutic implications are discussed.