论文部分内容阅读
曾经有人指出,心肌在缺氧后再行灌注的开始数分钟内将迅速吸取钠、水和钙,造成心肌细胞肿胀,在线粒体中形成致密的颗粒,这些颗粒中含有磷酸钙。为此,作者设计本组实验,试验下列3点假说:(1)心肌经低温缺氧45分钟和再灌注15分钟后给予钙盐能增强其收缩力,而又不致增加细胞的损伤;(2)再灌注15分钟后给予枸椽酸可能减少钙的摄取,从而保护心肌,减少细胞的损害;(3)在输入枸橡酸盐导致低钙的动物中,给予钙盐可扭转心肌收缩受抑制的状态,而不致增加其缺氧性损害。方法:26只杂种狗在全身麻醉下经左前胸切口进入胸膜腔,切开心包膜,压榨窦房结后,在右心室流出道上置起搏导线,应用起搏器将心室率固定在
It has been pointed out that myocardium rapidly absorbs sodium, water and calcium within a few minutes after reperfusion after hypoxia, resulting in swelling of cardiomyocytes and formation of dense granules in the mitochondria, which contain calcium phosphate. To this end, the author designed this group of experiments to test the following three hypotheses: (1) myocardial hypoxia 45 minutes and reperfusion 15 minutes after the given calcium salt can enhance their contractility without increasing cell damage; (2) ) 15 minutes after reperfusion citrate may reduce the calcium intake, thereby protecting the myocardium, reducing cell damage; (3) in the input of citrate led to low calcium animals, the administration of calcium salts can be reversed myocardial contraction is inhibited State, without increasing their hypoxic damage. Methods: Twenty-six hybrid dogs were injected into the pleural cavity through the left chest incision under general anesthesia. The pericardium was incised and the ventricular catheter was placed on the right ventricular outflow tract. The ventricular rate was fixed at