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以伯疟原虫(P.berghei K173)一小白鼠体内试验系统,研究青蒿素与周效磺胺—乙胺嘧啶的合理组方及其抗药性的作用。实验结果表明,青蒿素伍用周效磺胺—乙胺嘧啶(2:1)的最佳配比为20:0.05,三药伍用药效学呈相加型协同作用,其增效指数SD_(50)为7.3,SD__(90)为6.9。复方对鼠疟的治疗作用早期效果明显优于单药,但后期原虫转阴率及动物平均死亡时间与周效磺胺—乙胺嘧啶相似。复方抗性系的耐药剂量及抗性指数显著低于单药,提示复方对鼠疟有明显的延缓抗药性的作用,可能成为具有高效、速效及延缓抗药性作用的抗疟复方。
To P. berghei K173) a mouse in vivo test system to study the artemisinin and psoralel-pyrimethamine rational combination of prescription and its resistance role. The experimental results showed that the optimal ratio of artemisinin to sulfadiazine pyrimethamine (2: 1) was 20: 0.05, and the pharmacodynamics of the three drugs were synergistic. The synergistic index SD_ (50) is 7.3 and SD __ (90) is 6.9. The effect of the compound on the treatment of murine malaria was significantly better than the single drug, but the late protozoa negative rate and the average death time of animals and psoriasis similar to sulfa - pyrimethamine. The resistant dose and resistance index of the compound resistant lines were significantly lower than that of the single drug, suggesting that the compound has obviously delayed the resistance to the mouse malaria and may become an antimalarial compound with high efficiency, quick response and delayed drug resistance.