对促进新血管生成的物质的研究,经过十年的科学探索,现在已告完成。在发表的三篇文章中,Bert Vallee和他的同事们报道了他们称之为促血管生成素(angiogenin)的蛋白质的纯化以及该蛋白质基因的克隆。这项探索是在Judah Folkman开拓的工作基础上进行的。Folkman曾指出,肿瘤的生长需要营养,而营养是靠连续地向体内生长着的血管来供给。他还指出,一种可扩散的物质能引起血管的生成。Folkman将这种物质称为肿瘤的促血管生长因子(TAF—tumour angiogenesis factor)。研究工作大约进行了五年之后,Vallee和Folkman将他们的研究工作分成了两个独立的方向。Vallee认为促血管生成素(angiogenin)和TAF不 The study of substances that promote the formation of new blood vessels has been completed after ten years of scientific exploration. In the three published articles, Bert Vallee and his colleagues reported on the purification of the protein they called angiogenin and the cloning of the protein gene. This exploration was based on the work pioneered by Judah Folkman. Folkman once pointed out that the growth of tumors requires nutrition, and nutrition is supplied by blood vessels continuously growing in the body. He also pointed out that a diffusible substance can cause blood vessel formation. Folkman called this substance TAF-tumour angiogenesis factor. After about five years of research work, Vallee and Folkman divided their research work into two separate directions. Vallee thinks that angiogenin and TAF are not