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目的观察米力农联合硝普钠治疗顽固性心衰患者的疗效。方法顽固性心衰患者60例,随机分为治疗组及对照组各30例,两组患者性别、年龄、原发病种及病情相似。均给予足量利尿剂、血管紧张素转换酶抑制剂、硝普钠微量泵泵入、根据病情应用小剂量洋地黄类药物、营养支持及必要的抗感染治疗。治疗组在此基础上给予短期静脉应用米力农3~5d,观察两组患者临床症状改善情况及心脏各项指标变化。结果治疗组患者30例,心衰症状明显改善22例,有效8例,观察用药前后左室射血分数、左室舒张末期内径、心脏指数(CI)均有明显改善,与对照组相比差异有统计学意义(P<0.05)。结论米力农联合硝普钠治疗顽固性心衰能有效地提高射血分数,改善患者临床症状,近期内未增加死亡率。
Objective To observe the curative effect of Milrinone combined with sodium nitroprusside in patients with refractory heart failure. Methods Sixty patients with refractory heart failure were randomly divided into treatment group and control group, with 30 cases in each group. The two groups were similar in gender, age, primary disease and illness. All patients were given adequate diuretic, angiotensin converting enzyme inhibitor and nitroprusside micro pump. According to the disease, low-dose digitalis drugs, nutritional support and necessary anti-infective therapy were applied. The treatment group was given short-term intravenous Milrinone 3 ~ 5d on this basis to observe the clinical symptoms of both groups and changes in cardiac indicators. Results In the treatment group of 30 patients, the symptoms of heart failure were significantly improved in 22 cases and effective in 8 cases. The left ventricular ejection fraction, left ventricular end-diastolic diameter, and cardiac index (CI) were significantly improved before and after treatment, compared with the control group There was statistical significance (P <0.05). Conclusion Milrinone combined with sodium nitroprusside treatment of intractable heart failure can effectively improve the ejection fraction, improve the clinical symptoms of patients, no increase in mortality in the near future.