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目的研究注射用黄芪冻干粉(LRAPI)对犬心肌梗死的影响。方法冠状动脉结扎法造成心肌缺血模型。将麻醉犬分为模型组、丹参阳性对照组及LRAPI大、中、小剂量组,分别静脉给药,观察LRAPI对结扎所致犬心肌梗死范围、心电图、心肌耗氧量、血清酶学的影响。结果 LRAPI及丹参注射液均能显著降低心外膜心电图ST段偏移的总和,其中,LRAPI大剂量较丹参更为明显;同时,LRAPI高剂量组和丹参组大鼠的动脉血氧含量和心肌耗氧量呈显著降低趋势;而中、高剂量组的心肌氧摄取率于药后30～180min亦显著降低。此外,各药物均可显著降低心肌缺血犬的磷酸肌酸激酶(CK)和乳酸脱氢酶(LDH)活性;其中,LRAPI降低CK作用较丹参显著,LRAPI低剂量还显著降低LDH;其次,药物均可显著降低心肌梗死犬的心梗面积,其中,LRAPI大剂量降低心梗死面积作用明显强于丹参组。结论 LRAPI对犬心肌梗死有明显的改善作用。
Objective To investigate the effect of LRAPI injection on myocardial infarction in dogs. Methods Coronary artery occlusion caused myocardial ischemia model. The anesthetized dogs were divided into model group, Salvia miltiorrhiza positive control group and LRAPI large, medium and small dose groups, respectively, intravenous administration of LRAPI to observe the range of myocardial infarction caused by ligation, ECG, myocardial oxygen consumption, serum enzymology . Results Both LRAPI and Salvia miltiorrhiza injection could significantly reduce the sum of epicardial electrocardiogram ST segment shift. Among them, the high dose of LRAPI was more obvious than that of Salvia miltiorrhiza. At the same time, the arterial oxygen content and myocardial Oxygen consumption decreased significantly, while myocardial oxygen uptake rates of middle-dose and high-dose groups also decreased significantly after 30 ~ 180 min. In addition, all the drugs can significantly reduce the myocardial ischemia of creatine kinase (CK) and lactate dehydrogenase (LDH) activity; LRAPI reduce the role of CK than Salvia significantly lower dose of LRAPI also significantly lower LDH; secondly, Drugs can significantly reduce myocardial infarction dogs myocardial infarction area, which, LRAPI large dose to reduce myocardial infarction area was significantly stronger than Salvia group. Conclusion LRAPI can significantly improve myocardial infarction in dogs.